Alterations of myosin isoenzymes and ADP/ATP carrier in Goldblatt hypertensive rats (part 8)

Hypertrophy in which the rate of myosin ATPase activity and the velocity of muscle shortening are decreased without necessarily concordant heart failure has been defined as ‘pathological’. In the present study, our pressure overload-compensated hypertrophy model, the Goldblatt rat, meets the requirements for classification as ‘pathological’ according to the above authors. We feel that the decreased ATPase and dT/dt max values are part of a normal and beneficial response to new steady state systemic conditions. The decreased parameters in the pressure-overloaded heart are beneficial in that reduced ATPase reduces the risk of consumption of energy at a rate greater than the rate at which it can be supplied by metabolic processes.The ventricular myosin isoenzyme pattern shift towards V3 and the decrease in ventricular myosin ATPase activity in pressure-overloaded cardiac hypertrophy in the rat are considered to be an adaptation for maintenance of efficient force development, with low oxygen and energy utilization. If you want to make your online shopping advantageous and safe, check out the best pharmacy to buy order alegra without any need for a prescription, any time of the day or night with straight to the doorstep delivery.

A recent study revealed a correlation between imbalance of myocardial energy metabolism mediated by AAC antibody and heart function in patients with myocarditis and dilated cardiomyopathy . On the other hand, it has been shown that antibodies against AAC reduce cytosolic ATP and increase mitochondrial ATP concentrations.

This entry was posted in Hypertrophy and tagged ADP/ATP carrier, Goldblatt hypertensive rat, Hypertrophy, Myosin isoenzyme, Pyrophosphate gel electrophoresis.