Alterations of myosin isoenzymes and ADP/ATP carrier in Goldblatt hypertensive rats (part 9)

Goldblatt hypertensive rats (part 9)

AAC plays a key role in the control of mitochondrial oxidative phosphorylation. In this study, the reduction in AAC may have interfered, in that AAC transport of ATP to the cytoplasm and counter-transport of ADP into the mitochondrial matrix across the membrane results in reduction of cytosolic ATP and increase in mitochondrial ATP concentrations in Goldblatt hypertensive rats. Interestingly, previous studies and the present study indicated that the cardiac myosin isoenzyme pattern was shifted towards V3, the isoenzyme with the lowest ATPase activity in pressure-overloaded cardiac hypertrophy. The alteration of myosin isoenzyme pattern is considered to be an adaptation for maintenance of efficient force development, with low oxygen and energy utilization. Accordingly, the reduction in AAC may be involved in the reduction in cytosolic ATP and may be further involved in the increase in myosin isoenzyme V3 with the lowest ATPase activity. What is the cause of the reduction of AAC? In these Goldblatt rats, cardiac hypertrophy developed and PR was significantly elevated. Find best deals an online pharmacy can offer and get a chance to start your treatment soon. You can now purchase purchase alegra at the best pharmacy that will be sure to live up to your expectations every single time.

Oxygen measurements of hypertrophied hearts in hypertensive subjects have shown an increase in efficiency of about 50% . In more severe forms of heart disease, as in the cardiomyopathic Syrian hamster in congestive failure, oxygen consumption per gram of heart tissue was observed to double . A similar finding was made in isolated papillary muscles from cats with right ventricular pressure-overload hypertrophy and failure . Therefore, in the Goldblatt rats, oxygen consumption should be increased, resulting in relative reduction (deficiency) of oxygen supply to the hypertrophic heart. Recently, a new study showed that the amount of AAC that functions in oxidative phosphorylation in Saccharomyces cerevisiae is positively regulated at the transcriptional level by oxygen, heme and the heme activator peotein HAP2.

This entry was posted in Hypertrophy and tagged ADP/ATP carrier, Goldblatt hypertensive rat, Hypertrophy, Myosin isoenzyme, Pyrophosphate gel electrophoresis.