Small, short term studies have demonstrated that carvedilol is comparable with other beta-blockers (ie, propranolol, meto-prolol, labetalol, atenolol) with respect to blood pressure control and heart rate reduction . However, compared with other beta-blockers, carvedilol decreases peripheral vascular resistance to a greater extent . Unpublished clinical trials comparing carvedilol with other antihypertensives (ie, diuretics, ACE inhibitors, calcium channel blockers) have yielded similar efficacy rates. In addition, studies in hypertensive rat models have demonstrated that carvedilol decreases left ventricular hypertrophy , a long term complication of hypertension that increases the risk of cardiovascular morbidity and mortality. buy levaquin online
When beta-blockers are used in the management of hypertension, there is a reduction in renal blood flow and glomerular filtration rate (GFR) secondary to the reduction in cardiac output. In animal models, the alpha-blocking activity of carvedilol appears to preserve renal blood flow and GFR . This property may be beneficial in patients with preexisting renal dysfunction or patients with chronic hypertension at risk for hypertensive nephropathy.