Category Archives: Adult Rat Testis - Part 3

Local Regulation of Macrophage Subsets in the Adult Rat Testis: Examination of the Roles of the Seminiferous Tubules, Testosterone(2)

It has been established that these reductions are specifically due to the loss of functional Leydig cells rather than changes in circulating gonadotropin levels. Leydig cells have direct contact with testicular macrophages through intimate structural specializations. Leydig cells also produce locally high levels of androgens, and there is evidence that sex steroids including androgens have the potential to regulate some monocyte and macrophage functions (reviewed … Continue reading

Local Regulation of Macrophage Subsets in the Adult Rat Testis: Examination of the Roles of the Seminiferous Tubules, Testosterone(1)

Mononuclear phagocytes (monocytes and macrophages) represent a substantial cellular population in the normal testicular interstitial tissue of the human and experimental rodent species. In the adult rat testis, these cells belong to one of two distinct subsets, differentiated by the expression of the resident macrophage surface antigen recognized by monoclonal antibody ED2 and a lysosomal marker recognized by monoclonal antibody ED1. The majority of mononuclear … Continue reading