Category Archives: ARDS

Amiodarone and the Development of ARDS After Lung Surgery: Recommendations

In our retrospective evaluation, the incidence of ARDS after right-sided pneumonectomy was 7.4 percent compared with 1.6 percent in the other types of lung surgery. In the small group of 11 patients who received amiodarone after right-sided pneumonectomy in the prospective evaluation of prophylactic amiodarone therapy, ARDS occurred in 3 out of 11 patients. Greenspan etal described ARDS occurring after cardiac surgery for malignant arrhythmias … Continue reading

Amiodarone and the Development of ARDS After Lung Surgery: Conclusion

Direct toxic injury of lung parenchymal cells by amiodarone, regardless of the specific mechanisms, can trigger a repair process with widespread deposition of collagen that further deranges the alveolar capillary structures. Additionally, amiodarone may directly induce fibroblast replication in vitro, potentially facilitating the fibrotic response to amiodarone-mediated injury. Buy proventil in detail As pulmonary fibrosis occurs, gas exchange is further impaired and the chance for reversibility of … Continue reading

Amiodarone and the Development of ARDS After Lung Surgery: Discussion

The incidence of ARDS after the right pneumonectomy was 7.4 percent in all patients compared with 1.6 percent in the other types of lung surgery (x2 11.2; p<0.001), and in our retrospective study, ARDS was almost exclusively seen after the administration of amiodarone except after right-sided pneumonectomy. The evaluation of prophylactic antiarrhythmic treatment with amiodarone was stopped because the development of ARDS seemed related to … Continue reading

Amiodarone and the Development of ARDS After Lung Surgery: Results

Right-heart catheterization was performed in these three patients and showed normal pulmonary wedge pressures and normal cardiac output on each occasion. Treatment with amiodarone was stopped after a total dose of 2,150 mg in the first, 3,750 mg in the second, and 3,350 mg in the third patient. Plasma levels of amiodarone and desethylamio-darone (Table 2) were similar and within expected limits in all pneumonectomy … Continue reading

Amiodarone and the Development of ARDS After Lung Surgery: Methods

The treatment routinely used after a pulmonary operation, ie, prophylactic antibiotics, subcutaneous low molecular weight heparin, and an H2 antagonist IV, was given as usual. Other forms of treatment were given as required. The prophylactic antiarrhythmic treatment was interrupted when side effects occurred, which were thought to be related to the antiarrhythmic drug such as rhythm or conduction disturbances and hypotension, or when other and … Continue reading

Amiodarone and the Development of ARDS After Lung Surgery

Atrial dysrhythmias—fibrillation, flutter, or paroxysmal atrial tachycardias—are frequently occurring arrhythmias after thoracic surgery. Besides the hemodynamic consequences and the need for immediate treatment, atrial fibrillation has severe prognostic implications for patients after pneumonectomy, of which a postoperative mortality of 25 percent has been reported. Several prophylactic strategies with antiarrhyth-mic drugs, mostly digitalis or beta-blocking agents, have been evaluated for the prophylaxis of atrial fibrillation after … Continue reading