Category Archives: Cardiac Surgery

Hemodynamic and Renal Effects of Dopexamine and Dobutamine in Patients With Reduced Cardiac Output Following Coronary Artery Bypass Grafting: Materials

Incremental doses of 1 or 3 ^g/kg/min of dopexamine and 2.5 or 7.5 /ug/kg/min of dobutamine were used if the patient could not tolerate the stated dosages. During the intensive care unit (ICU) maintenance phase of the study (from 1 h after starting the study drug to the end of the 24-h study period), adjustment of drug dosages was titrated only if Cl fell below … Continue reading

Hemodynamic and Renal Effects of Dopexamine and Dobutamine in Patients With Reduced Cardiac Output Following Coronary Artery Bypass Grafting: Methods

This study was approved by the Institutional Review Board prior to the recruitment of patient subjects. Twenty-eight patients undergoing elective CABG with preoperative left ventricular ejection fraction of at least 40 percent (determined by contrast ventriculography at the time of cardiac catheterization) provided written informed consent. Patients excluded from the study included those with acute myocardial infarction within 1 month of surgery, diabetes, severe peripheral … Continue reading

Hemodynamic and Renal Effects of Dopexamine and Dobutamine in Patients With Reduced Cardiac Output Following Coronary Artery Bypass Grafting

Left ventricular dysfunction is frequently encountered following invasive cardiac surgical procedures, including coronary artery bypass grafting (CABG). Treatment options for improving cardiac function after CABG include B-adrenergic agonists (epinephrine, dobutamine, and dopamine), phosphodiesterase inhibitors (amrinone and milrinone), vasodilators (nitroprusside and nitroglycerine), and in-tra-aortic balloon counter pulsation 2 Dobutamine is commonly used after CABG, in part due to the beneficial effect of combining positive inotropic support … Continue reading