Category Archives: Cystic Fibrosis

Effect of High-Frequency Chest Wall Oscillation on the Central and Peripheral Distribution of Aerosolized Diethylene Triamine Penta-acetic Acid as Compared to Standard Chest Physiotherapy in Cystic Fibrosis: Conclusions

When comparing the severity of obstruction (FEV1 percentage of predicted, FVC percentage of predicted, FEV1/FVC) with the mean C/P ratio, we could not demonstrate the expected inverse correlation between these two variables. This, in part, may be because the range of lung function for our population was somewhat narrower. Our population contained patients with more severe disease not uncommon in adults with CF (Table 1). … Continue reading

Effect of High-Frequency Chest Wall Oscillation on the Central and Peripheral Distribution of Aerosolized Diethylene Triamine Penta-acetic Acid as Compared to Standard Chest Physiotherapy in Cystic Fibrosis: Discussion

We were unable to detect any decremental effect of combined HFCWO and aerosol treatment in the C/P ratio. In addition, no significant correlation was found between the C/P ratio and the level of lung function in the HFCWO group. Virtually all CF patients require daily aerosolized medications during the course of their disease. Maximizing the administration of these medications and ensuring appropriate delivery of antibiotics … Continue reading

Effect of High-Frequency Chest Wall Oscillation on the Central and Peripheral Distribution of Aerosolized Diethylene Triamine Penta-acetic Acid as Compared to Standard Chest Physiotherapy in Cystic Fibrosis: Results

Images obtained after nebulization of aerosolized DTPA were transposed onto the Xe images. An ROI was drawn around the stomach to identify gastric radioactivity. Figure 1 shows a representative study. The amount of this activity compared to overall counts was small; however, the stomach images were removed before the data were analyzed. The C/P ratio of each lung determined by the pixel counts in those … Continue reading

Effect of High-Frequency Chest Wall Oscillation on the Central and Peripheral Distribution of Aerosolized Diethylene Triamine Penta-acetic Acid as Compared to Standard Chest Physiotherapy in Cystic Fibrosis: Patient Protocol

Immediately following Xe administration, 4 mL or approximately 40 mCi of 99mTc diethylene triamine penta-acetic acid (DTPA) was nebulized. Aerosolization of DTPA yields particle sizes of 1 to 5 |j,m, similar to nebulized medications, and is commonly used as a radiolabeled aerosol for determining regional pulmonary distribution. DTPA was nebulized (Pari LC Plus; Pari Respiratory Equipment; Richmond, VA) for 15 min. All nebulizations were performed … Continue reading

Effect of High-Frequency Chest Wall Oscillation on the Central and Peripheral Distribution of Aerosolized Diethylene Triamine Penta-acetic Acid as Compared to Standard Chest Physiotherapy in Cystic Fibrosis: Materials and Methods

Ten patients (3 female and 7 male) with CF were studied in a randomized crossover design following informed consent approved by the Human Subjects Committee and Radiation Safety Committee at the University of Kansas Medical Center. The history of a positive sweat chloride test result and the presence of sinopulmonary disease confirmed the diagnosis of CF. Patients were included if they did not have symptoms … Continue reading

Effect of High-Frequency Chest Wall Oscillation on the Central and Peripheral Distribution of Aerosolized Diethylene Triamine Penta-acetic Acid as Compared to Standard Chest Physiotherapy in Cystic Fibrosis: Study

Furthermore, there is evidence that HFCWO removes secretions by generating differences between expiratory and inspiratory flow and velocity. Several studies have suggested that HFCWO is as effective as SCPT. In addition to the airway clearance effect, HFCWO has been shown to enhance nitrogen washout, suggesting that alveolar ventilation may be increased during HFCWO as well. so More than 50 patients in our Adult Cystic Fibrosis … Continue reading

Effect of High-Frequency Chest Wall Oscillation on the Central and Peripheral Distribution of Aerosolized Diethylene Triamine Penta-acetic Acid as Compared to Standard Chest Physiotherapy in Cystic Fibrosis

CIystic fibrosis (CF), a disease of chronic bronchial infection, airway obstruction, progressive loss of lung function. Daily health maintenance consists of airway clearance therapy (ACT), antibiotics, dornase alfa, and bronchodilators, and can be very time consuming for CF patients. More than 50% of patients at our institution reported spending > 1 h/d administering ACT and aerosolized medications. Nearly all patients admitted noncompliance with ACT, with … Continue reading

Impact of Pregnancy on Women With Cystic Fibrosis: Conclusions

We noted an increase in the use of nutritional therapies during and after pregnancy. This finding is consistent with the increasing caloric needs associated with pregnancy and breastfeeding; recommendations for these therapies are supported by both obstetric and CF caregivers. The increased frequency of CF clinic visits is likely due to the perceived need for increased monitoring of disease status as well as the need … Continue reading

Impact of Pregnancy on Women With Cystic Fibrosis: Discussion

To further test the reliability of the differences that we observed, we examined the same variables for the 18 to 36 months before the index visit and for the 18 to 36 months following the pregnancy period in a subgroup of patients with available data (n = 83). Group differences remained similar across all five time periods of comparison, indicating a constant difference between the … Continue reading

Impact of Pregnancy on Women With Cystic Fibrosis: Results

During the baseline period, the women who later became pregnant were seen an average of 5.4 times per year for outpatient clinical care compared to 4.7 times per year for the nonpregnant cohort (p < 0.001). Clinic visits were 33% more frequent during pregnancy compared to the baseline period (7.2 vs 5.4 visits per year, respectively; p < 0.001). However, in the follow-up period, the … Continue reading