Category Archives: Pulmonary Function - Part 2

Evidence of Innervation in Talc-Induced Pleural Adhesions: Results

All rabbit pleural adhesions examined in this study were mesothelial-covered fibrovascular bands containing well-developed blood and lymphatic vessels establishing a structural continuity between both pleural layers (Fig 1, top, A). Myelinated nerve fibers were also present in adhesions from 20% (2 of 10 rabbits). In addition, polarized light microscopy revealed that foreign body granulomas of variable size were common histopathologic findings in most of the … Continue reading

Evidence of Innervation in Talc-Induced Pleural Adhesions: Study Design and Procedures

Ten white, male, New Zealand rabbits weighing 1.5 to 2.0 kg were used in the present study. Right thoracotomy was performed at the seventh intercostal space, as previously described in detail, and 200 mg/kg of talc (mean ± SEM maximum diameter, 8.36 ± 0.20 |j,m; Distalc; Barcelona, Spain) suspended in 2 mL of endotoxin-free saline solution were instilled into the pleural cavity. This dose was … Continue reading

Evidence of Innervation in Talc-Induced Pleural Adhesions

Pleurodesis is a well-established therapeutic method for the treatment of recurrent spontaneous pneumothoraces and relapsing symptomatic pleural effusions of different etiologies.,2 The goal of pleurodesis is to achieve the symphysis of visceral and parietal pleura in order to impede the accumulation of air or fluid in the pleural cavity. To date, many agents have been proposed as useful for pleurodesis, although many of them have … Continue reading

Mycophenolate Mofetil Is Safe, Well Tolerated, and Preserves Lung Function in Patients With Connective Tissue Disease-Related Interstitial Lung Disease: Conclusion

There are few studies that offer guidance in the treatment of CTD-ILD, and perhaps the most valid ones come from those examining treatment strategies for patients within the scleroderma spectrum of disease. In that paradigm, patients with “alveolitis,” as demonstrated by ground-glass opacities on HRCT or either neutrophilia or eosinophilia on BAL, are treated with CYC because of the high likelihood that the lung parenchymal … Continue reading

Mycophenolate Mofetil Is Safe, Well Tolerated, and Preserves Lung Function in Patients With Connective Tissue Disease-Related Interstitial Lung Disease: Discussion

In this study, 28 subjects with CTD-ILD received MMF for nearly 36 patient-years. MMF was very well tolerated; only two patients discontinued MMF for any reason. In contrast, prior to being started on MMF, 15 patients discontinued other immunomodulatory agents, most because of adverse effects. In addition, MMF maintained pulmonary physiology without increasing the median daily dose of glucocorticoids. Values for FVC, TLC, and Dlco … Continue reading

Mycophenolate Mofetil Is Safe, Well Tolerated, and Preserves Lung Function in Patients With Connective Tissue Disease-Related Interstitial Lung Disease: Research

While being treated with MMF, five patients had worsening respiratory symptoms, pulmonary physiology, or HRCT scans a median of 700 days (range, 211 to 1,105 days) after MMF initiation, which prompted either an increase in daily MMF or in prednisone dose. The average increase in daily prednisone dose over baseline in these cases was 14.5 mg; the average maximal prednisone dose during these episodes was … Continue reading

Mycophenolate Mofetil Is Safe, Well Tolerated, and Preserves Lung Function in Patients With Connective Tissue Disease-Related Interstitial Lung Disease: Results

A total of 67 patients were being treated with MMF. Twenty-eight patients received MMF primarily for CTD-ILD. The other 39 patients were excluded for the following reasons: (1) 29 patients had CTD but no ILD; (2) 6 patients with CTD-ILD had not yet returned for a follow-up visit; and (3) 4 patients had an idiopathic interstitial pneumonia (nonspecific interstitial pneumonia). Sixty-four percent (n = 18) … Continue reading

Mycophenolate Mofetil Is Safe, Well Tolerated, and Preserves Lung Function in Patients With Connective Tissue Disease-Related Interstitial Lung Disease: Statistical Analysis

Data are presented as counts or either as medians with full or interquartile ranges or as means with SDs. storehealthmall.eu The effect of MMF on lung function was examined by using longitudinal data analytic methods. Longitudinal models were utilized to examine each of three continuous pulmonary physiology variables (FVC, total lung capacity [TLC], and diffusing capacity of the lung for carbon monoxide [Dlco]). Each model modeled … Continue reading

Mycophenolate Mofetil Is Safe, Well Tolerated, and Preserves Lung Function in Patients With Connective Tissue Disease-Related Interstitial Lung Disease: Materials and Methods

However, experience with using MMF for CTD-ILD is extremely limited. We conducted this study to analyze the experience of our center with treating CTD-ILD patients with MMF. Our primary objective was to evaluate the safety and tolerability of using MMF in a heterogeneous sample of patients with various CTD-ILDs. A secondary objective of this study was to examine the impact of MMF on pulmonary physiology … Continue reading

Mycophenolate Mofetil Is Safe, Well Tolerated, and Preserves Lung Function in Patients With Connective Tissue Disease-Related Interstitial Lung Disease

The connective tissue diseases (CTDs) are a heterogeneous group of disorders characterized by inflammatory and fibrotic tissue injury. The lung is commonly affected by CTD. Because of the abundant connective tissue in the lung (and perhaps because of its large blood supply), any of its compartments (airways, parenchyma, vasculature, or pleura)—and not uncommonly multiple compartments simultaneously—are affected in cases of CTD, The interstitial lung diseases … Continue reading