Category Archives: Spermatogenesis

EPAS1 Is Required for Spermatogenesis in the Postnatal Mouse Testis

Mammalian spermatogenesis is a complex process involving precisely regulated stem cells, coordinated hormone and growth factor signaling, and a maturation and release process that ensures sperm production throughout masculine life. Germ cells are specified and separated from somatic cells during early embryogenesis. As the embryonic testes are formed, Sertoli cells sequester gonocytes inside the newly formed seminiferous tubules (testicular cords), preventing them from entering meiosis. … Continue reading