Genetic testing is useful in the diagnosis of nonhereditary pancreatic conditions: PRSS1 MUTATIONS Part 2

Genetic testing

PRSS1 MUTATIONS Part 2Genetic testing for hereditary pancreatitis has been available for research and clinical purposes for the past five years. The major issues surrounding genetic testing were recently reviewed. In general, the indications for clinical genetic testing vary widely according to the severity of the disease, the age of onset, the availability of surrogate markers and the possibility of an effective intervention. Patients are also likely to have their own reasons for pursuing genetic testing. Reasons for PRSS1 mutation testing generally include verification of a clinical suspicion, helping patients to understand or validate their condition, and assisting individuals at risk of pancreatitis (and ultimately pancreatic cancer) in making lifestyle decisions (involving diet and smoking, for example) that minimize the risk of disease. Indeed, identification of an established pancreatitis-associated gene mutation can be valuable in expediting the evaluation of recurrent pancreatitis in children and preventing the unnecessary pursuit of elusive causes of pancreatitis in adults (eg, sphincter of Oddi dysfunction or occult alcohol abuse). A consensus statement on genetic testing for suspected hereditary pancreatitis was developed at the Third International Symposium on Inherited Diseases of the Pancreas (in Milan, Italy, in April 2001), and has been published in a special issue of the journal Pancreatology. Such investigations are meant for patients with a clinical and family history suggestive of hereditary pancreatitis. Buy best quality medications online at the pharmacy that will make sure your are happy with the prices and the quality of your birth control mircette whenever you need some treatment and have no idea where to get it.

This entry was posted in Pancreatic and tagged Cystic fibrosis transmembrane conductance regulator, Kazal type 1, Pancreatic secretory trypsin inhibitor, Serine protease inhibitor, Trypsin, Trypsinogen.