Local Regulation of Macrophage Subsets in the Adult Rat Testis: DISCUSSION(7)

DISCUSSION(7)

In the present study, s.c. T-implants partially reversed the increase in IF volume that follows the loss of normal vascular regulatory influences from the seminiferous tubules in the cryptorchid testis. These data suggest that the accumulation of IF following seminiferous tubule damage is partially dependent upon gonadotropin action. This effect is most likely mediated by LH, which stimulates IF volume in other physiological and pathophysiological conditions. Interestingly, there also was a relationship between the number of long-term resident macrophage numbers and the volume of the IF, which may indicate an as yet unidentified role for these cells in controlling vascular responses in the testis. canadian family pharmacy com

Consistent with previous observations, peripheral testosterone levels were effectively normal in the bilaterally cryptorchid rats, as indicated by the seminal vesicle and thymus weights. Testicular IF testosterone levels also appeared to be either normal or slightly elevated in the cryptorchid rat. Although similar results have been reported elsewhere, this latter observation was analyzed further because it was not consistent with previous results obtained in our laboratory and in some other laboratories using the same experimental model. Continued synthesis of testosterone after testis collection, leading to artificially elevated testosterone levels in testicular IF, has been raised previously as a potential technical problem.

This entry was posted in Adult Rat Testis and tagged Adult Rat Testis, Inhibitory Factor, Macrophage, Seminiferous Tubules, Testosterone.