Local Regulation of Macrophage Subsets in the Adult Rat Testis: RESULTS(4)

Total testicular macrophage numbers (i.e., all ED1+ cells and ED2+ cells) declined by approximately 40-50% in T3-implanted and in T24-implanted rat testes (Fig. 6A). This decline was primarily the result of a 40% reduction in the number of resident macrophages (ED2+ cells only) (Fig. 6B). There was a more pronounced decline (75%) in the less numerous ED1+ED2~ monocyte/macrophage subset in the T3-implanted animals, while the numbers of this subset were maintained in the T24-implanted group (Fig. 6C). The ED2+ED1~ (long-term resident) macrophages comprised between 25-43% of the ED2+ macrophage population across all treatment groups, and no significant difference in the number of ED2+ED1~ between the treatment groups was detected (data not shown). buy ortho tri-cyclen

In spite of the large increase in macrophage density observed in the abdominal testis (Table 1), there was no change in the total number of intratesticular monocyte/macrophage or resident macrophages (Fig. 6, A and B). This apparent discrepancy between cell density and number was due to the very large decrease in testis volume following cryptorchidism.
Fig6Local Regulation
FIG. 6. Total testicular macrophages (A), ED2+ resident testicular macrophages (B), and ED1+ED2- testicular monocyte/macrophages (C) in adult rats with scrotal or abdominal testes without implants (C, Co), with T3-implants, or with T24-implants. Values with same letter subscript are not significantly different (p > 0.05).

This entry was posted in Adult Rat Testis and tagged Adult Rat Testis, Inhibitory Factor, Macrophage, Seminiferous Tubules, Testosterone.