Local Regulation of Macrophage Subsets in the Adult Rat Testis: RESULTS(5)


In contrast to observations in the scrotal testis, the number of ED1+ED2~ monocyte/macrophages was not significantly different from normal control levels in any abdominal testis regardless of the presence or absence of either length of T-implant (Fig. 6C). However, the T24-implants did partially restore ED2+ resident macrophage numbers in the abdominal testis (Fig. 6B) without any apparent effect on the number of ED1+ED2~ monocyte/macrophages (Fig. 6C). flovent inhaler

When the data for all experimental groups were combined, testicular ED2+ resident macrophage numbers showed a significant positive correlation with LH, seminal vesicle weight (data not shown), and intratesticular testosterone levels (Fig. 7A)—parametersthat eeindicatorsof Leydig cell activity. There was an inverse relationship between MIF levels and resident macrophage numbers (Fig. 7B). In the untreated control rats only, both total monocyte/ macrophages and total ED2+ resident macrophage numbers were directly related to testis weight (r = 0.84 and r = 0.85, respectively; n = 6 animals, p < 0.05). However, no relationship was detected between resident ED2+ macrophage numbers and testis weight (r = 0.1, p > 0.05) or IF volume (r = 0.3, p > 0.05) when all experimental groups were combined.
Fig7Local Regulation
FIG. 7. Correlation analysis of combined data for all rats from each experimental group (n = 36 animals in total): ED2+ resident testicular macrophages with IF testosterone levels (A) and MIF immunoreactivity levels (B), ED2 + ED1- long-term resident macrophages with ED1+ED2- monocyte/macrophages (C), and IF volume with ED2 + ED1- long-term resident macrophages (D).

This entry was posted in Adult Rat Testis and tagged Adult Rat Testis, Inhibitory Factor, Macrophage, Seminiferous Tubules, Testosterone.