Tedisamil enhances intercellular coupling: A new explanation of its antiarrhythmic defibrillating effects (part 5)

defibrillating effects (part 5)

Following this assumption and the fact that sotalol enhances intercellular coupling, most probably by increasing intracellular cAMP concentration, the aim of this study was to examine the effect of tedisamil on myocardial intercellular coupling. Intercellular coupling was examined, as in the previous studies , by observing the spread of intracellulary injected Lucifer yellow CH dye to the neighbouring cells in right ventricular muscle strip of guinea pig heart. As explained previously, in this set-up measurement can only be in an on/off manner (decoupling, recoupling or prevention of decoupling). For this reason we examined the effect of tedisamil on the background of intercellular decoupling caused by either high Ca2+ or hypoxic normal Tyrode’s solution. These two experimental conditions were chosen because they both are known to occur during VF, decreasing myocardial intercellular coupling .Our results demonstrate that administration of tedisamil either prevents or restores high Ca2+- or hypoxia-induced decoupling by increasing junctional permeability. These results suggest that, like sotalol , tricyclic antidepressants, adrenaline and other sympathomimetic compounds , tedisamil increases intercellular permeability. The de-fibrillating effect of tedisamil could be, therefore, attributed to its ability to enhance intercellular coupling, which, most likely, leads to an increase in intercellular synchronization and supports spontaneous defibrillation. Take advantage of this chance to find viagra super active online and save quite some money.

This entry was posted in Cardiology, Tedisamil and tagged Class III antiarrhythmic drugs, Intercellular coupling, Spontaneous defibrillation, Tedisamil.